THE ROLE OF ADPRT 2285 A>G RS1136410 GENE POLIMORPHISM IN THE FORMING OF SUSCEPTIBILITY TO THE DEVELOPMENT OF BREAST CANCER
Authors:
4.
Kemerovo State University
Kemerovo, Kemerovo, Russian Federation
Kemerovo, Kemerovo, Russian Federation
Type:
Сonference abstract
Published:
16.02.2023
Subject area:
UDK 57 Биологические науки
Language:
Russian
Keywords:
breast cancer, ADPRT gene polymorphism
Abstract (English):
Breast cancer (BC), with nearly 1.7 million incidence and 522,000 deaths (according to GLOBOCAN statistics), is the most frequently occurring cancer in women. The etiology of BC is multifactorial and has not been fully elucidated. However, genetic factors are known to increase or decrease susceptibility to BC, suggesting that genetic polymorphisms play an important role in the oncopathology. Accordingly to these facts, the aim of our study was the analysis of polymorphic variants of DNA repair genes ADPRT 2285 A>G rs113641 in BC patients and conditionally healthy women of Kemerovo region.
Breast cancer (BC), with nearly 1.7 million incidence and 522,000 deaths (according to GLOBOCAN statistics), is the most frequently occurring cancer in women. The etiology of BC is multifactorial and has not been fully elucidated. However, genetic factors are known to increase or decrease susceptibility to BC, suggesting that genetic polymorphisms play an important role in the oncopathology. Accordingly to these facts, the aim of our study was the analysis of polymorphic variants of DNA repair genes ADPRT 2285 A>G rs113641 in BC patients and conditionally healthy women of Kemerovo region.
Keywords:
breast cancer, ADPRT gene polymorphism
breast cancer, ADPRT gene polymorphism
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2. Xin, Y. PARP1 rs1136410 Val762Ala contributes to an increased risk of overall cancer in the East Asian population: a meta-analysis / Y. Xin [et al.] // Journal of International Medical Research. 2021. Vol. 49(3). pp. 1-13.
