Vaccinomics, as one of the areas of personalized medicine, can increase the effectiveness of vaccines, including in epidemics. Nevertheless, it is accompanied by a cluster of bioethical issues. The article explores possible bioethical difficulties associated with the development of personalized vaccines: the matching of the research subject and the person receiving the vaccine; the problem of confidential genetic data; equitable distribution of medical resources.
vaccinomics, vaccine development, bioethics, confidentiality of genetic data, equitable distribution of medical resources
1. Farhart C.E. et al. Vax attacks: How conspiracy theory belief undermines vaccine support // Progress in Molecular Biology and Translational Science. Elsevier B.V., 2022. Vol. 188, № 1. P. 135-169. doi:https://doi.org/10.1016/bs.pmbts
2. Omersel J., Kuželički N.K. Vaccinomics and adversomics in the era of precision medicine: A review based on hbv, mmr, hpv, and covid-19 vaccines // Journal of Clinical Medicine. MDPI, 2020. Vol. 9, № 11. P. 1-22. doi:https://doi.org/10.3390/jcm9113561
3. Poland G. A. et al. Vaccinomics and a new paradigm for the development of preventive vaccines against viral infections // OMICS: A Journal of Integrative Biology. 2011. Vol. 15, № 9. P. 625-636. doi:https://doi.org/10.1089/omi.2011.0032
4. Gerber J.E. et al. Ethical and policy implications of vaccinomics in the United States: community members’ perspectives // Hum Vaccin Immunother. Bellwether Publishing, Ltd., 2021. Vol. 17, № 7. P. 2133-2144. doi:https://doi.org/10.1080/21645515.2020.1859318
5. Joly Y. et al. Diagnostic testing for vaccinomics: Is the regulatory approval framework adequate? A comparison of Canada, the United States, and Europe // OMICS: A Journal of Integrative Biology. 2011. Vol. 15, № 9. P. 597-605. doi:https://doi.org/10.1089/omi.2010.01356. - sentr. URL:https://www.levada.ru/2021/07/05/koronavirus-privivki-i-obyazatelnaya-vaktsinatsiya/(assessed23.09.2022).
6. Koronavirus, privivki i obyazatel'naya vakcinaciya// LEVADA-Centr.URL: https://www.levada.ru/2021/07/05/koronavirus-privivki-i-obyazatelnaya-vaktsinatsiya/ (data obrascheniya: 23.09.2022).
7. Beauchamp, T., Childress J. Principles of biomedical ethics. 8th ed. New York: Oxford University Press. 2019
